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KMID : 0812020130190020227
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Korean Journal of Neurogastroenterology and Motility
2013 Volume.19 No. 2 p.227 ~ p.232
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Early Effect of Single-dose Sitagliptin Administration on Gastric Emptying: Crossover Study Using the 13C Breath Test
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Nonaka Takashi
Sekino Yusuke
Iida Hiroshi
Yamada Eiji
Ohkubo Hidenori
Sakai Eiji
Higurashi Takuma
Hosono Kunihiro
Endo Hiroki
Koide Tomoko
Takahashi Hirokazu
Fujita Koji
Yoneda Masato
Goto Ayumu
Kusakabe Akihiko
Kobayashi Noritoshi
Gotoh Eiji
Maeda Shin
Nakajima Atsushi
Nosaka Chihiro
Inamori Masahiko
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Abstract
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Background/Aims The gastrointestinal motility effects of endogenous incretin hormones enhanced by dipeptidyl peptidase-IV (DPP-IV) inhibitors have not yet been sufficiently investigated. The aim of this study was to determine whether single pre-prandial sitagliptin, the DPP-IV inhibitor, administration might have an effect on the rate of liquid gastric emptying using the 13C-acetic acid breath test. Methods Ten healthy male volunteers participated in this randomized, two-way crossover study. The subjects fasted for overnight and were randomly assigned to receive 50 mg sitagliptin 2 hours before ingestion of the liquid test meal (200 kcal per 200 mL, containing 100 mg 13C-acetate) or the test meal alone. Under both conditions, breath samples were collected for 150 minutes following the meal. Liquid gastric emptying was estimated by the values of the following parameters: the time required for 50% emptying of the labeled meal (T1/2), the analog to the scintigraphy lag time for 10% emptying of the labeled meal (Tlag), the gastric emptying coefficient and the regression-estimated constants (b and ?), calculated by using the 13CO2 breath excretion curve using the conventional formulae. The parameters between the 2 test conditions were compared statistically. Results No significant differences in the calculated parameters, including T1/2, Tlag, gastric emptying coefficient or b and ?, were observed between the 2 test conditions. Conclusions The present study revealed that single-dose sitagliptin intake had no significant influence on the rate of liquid gastric emptying in asymptomatic volunteers.
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KEYWORD
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Breath tests, Gastric emptying, Sitagliptin
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